On 10 March 1975, General Dung launched Campaign 275, a limited offensive into the Central Highlands, supported by tanks and heavy artillery. The target was Ban Me Thuot, in Daklak Province. If the town could be taken, the provincial capital of Pleiku and the road to the coast would be exposed for a planned campaign in 1976. The ARVN proved incapable of resisting the onslaught, and its forces collapsed on 11 March. Once again, Hanoi was surprised by the speed of their success. Dung now urged the Politburo to allow him to seize Pleiku immediately and then turn his attention to Kon Tum. He argued that with two months of good weather remaining until the onset of the monsoon, it would be irresponsible to not take advantage of the situation.

President Nguyễn Văn Thiệu, a former general, was fearful that his forces would be cut off in the north by the attacking communists; Thieu ordered a retreat. The president declared this to be a "lighten the top and keep the bottom" strategy. But in what appeared to be a repeat of Operation Lam Son 719, the withdrawal soon turned into a bloody rout. While the bulk of ARVN forces attempted to flee, isolated units fought desperately. ARVN General Phu abandoned Pleiku and Kon Tum and retreated toward the coast, in what became known as the "column of tears".

As the ARVN tried to disengage from the enemy, refugees mixed in with the line of retreat. The poor condition of roads and bridges, damaged by years of conflict and neglect, slowed Phu's column. As the North Vietnamese forces approached, panic set in. Often abandoned by the officers, the soldiers and civilians were shelled incessantly. The retreat degenerated into a desperate scramble for the coast. By 1 April the "column of tears" was all but annihilated.

On 20 March, Thieu reversed himself and ordered Huế, Vietnam's third-largest city, be held at all costs, and then changed his policy several times. Thieu's contradictory orders confused and demoralized his officer corps. As the North Vietnamese launched their attack, panic set in, and ARVN resistance withered. On 22 March, the VPA opened the siege of Huế. Civilians flooded the airport and the docks hoping for any mode of escape. Some even swam out to sea to reach boats and barges anchored offshore. In the confusion, routed ARVN soldiers fired on civilians to make way for their retreat.

On 31 March, after a three-day battle, Huế fell. As resistance in Huế collapsed, North Vietnamese rockets rained down on Da Nang and its airport. By 28 March, 35,000 VPA troops were poised to attack the suburbs. By 30 March 100,000 leaderless ARVN troops surrendered as the VPA marched victoriously through Da Nang. With the fall of the city, the defense of the Central Highlands and Northern provinces came to an end.